Skolnik, Suzanne, Barrett, Jaclyn, Yang, Wenzhan, Belliveau, Lisa and Patros, Kellyn (2022) Discovery solubility measurement and assessment with drug development in mind. Drug discovery today. ISSN 13596446

Abstract

Solubility is a key physicochemical property for the success of any drug candidate. While the methods used and their rationales for determining solubility are subject to project needs and stages along the drug discovery-drug development pipeline, an artificial boundary may exist at the discovery- development interface. This boundary results in less effective solubility knowledge sharing and data integration among scientists in both drug discovery and drug development. Herein, we present a refreshed perspective on solubility. Solubility experimentation is not a one size fits all measurement; instead, we stress the importance of constructing a seamless solubility understanding of a molecule as it progresses from a new chemical entity into a drug product. Expect, welcome, and brace yourself for an evolution thereof.

Item Type:	Article
Keywords:	solubility approach, drug discovery, early drug development, experimental design, data interpretation
Date Deposited:	15 Feb 2022 00:45
Last Modified:	15 Feb 2022 00:45
URI:	https://oak.novartis.com/id/eprint/45529