Wolf, Thomas, Meishammer, Aldo, Patissier, Celine, Reck, Marcel, Valente, Claudio and Reilly, John (2021) Achiral SFC for Purification of Pharmaceuticals. Chromatography Today , Nov 20. pp. 12-14.

Abstract

With large quantities of small scale (<1000mg) separations typically being needed to be purified and evaluated for discovery in-vitro and in-vivo testing regimes, a chromatographic purification technique needs to be easily integrated into discovery chemistry laboratories and highly reproducible. HPLC has been generally accepted as the main technique of choice for analysis and purification, utilizing either normal phase or reverse phase conditions, with reverse phase being the generally accepted as a high throughput approach to purify small scale drug discovery products At Novartis, the integration of supercritical fluid chromatography (SFC) has several advantages such as faster run times due to lower viscosity, short equilibration times, reduced solvent consumption and, in preparative applications, fast solvent removal. SFC has rapidly become a very attractive alternative to Normal Phase and Reverse Phase purification for achiral samples and this short article highlights the benefits of this approach.

Item Type:	Article
Date Deposited:	13 Jan 2022 00:45
Last Modified:	13 Jan 2022 00:45
URI:	https://oak.novartis.com/id/eprint/45523