Plummer, Scott, Robinson, Richard, Smith, Marie, Chang, Jim, Lipschutz, Bruce, Wood, Alex and Gallou, Fabrice (2021) Continuous Slurry Plug Flow Fe/ppm Pd Nanoparticle-Catalyzed Suzuki-Miyaura Couplings in Water Utilizing Novel Solids Handling Equipment. Green Chemistry, 23 (19). pp. 7724-7730. ISSN 1463-92621463-9270

Abstract

Herein are reported initial efforts to develop a generally accessible flow process, applying a heterogenous nanocatalyst to aqueous micelle-enabled Suzuki-Miyaura coupling reactions. Also disclosed is a new engineering solution (i.e., a self-draining back pressure regulator), which, when applied, enabled 1.5 hours of continuous operation leading to the production of 20 grams of a pharmaceutical intermediate.

Item Type:	Article
Date Deposited:	25 Feb 2022 00:45
Last Modified:	25 Feb 2022 00:45
URI:	https://oak.novartis.com/id/eprint/45328