Differential role of NR2A and NR2B subunits in NMDA receptor antagonist-induced cortical gamma oscillations
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Kocsis, Bernat (2012) Differential role of NR2A and NR2B subunits in NMDA receptor antagonist-induced cortical gamma oscillations. Biological Psychiatry, 1 (17). pp. 987-995. ISSN 0006-3223
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Abstract
NMDA-R antagonists elicit psychotic symptoms in human and schizophrenia-relevant signs in rodents, including a strong increase in cortical gamma activity. We show that this phenomenon primarily depends on a specific subtype of NMDA-Rs which contains the NR2A subunit whereas blockade of NR2B, C, or D subunit-containing receptors do not elicit such massive gamma oscillations. Both NR2A and NR2B-selective NMDA-R antagonists induce, however, long-lasting elevations of gamma power specifically during REM sleep.
| Item Type: | Article |
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| Additional Information: | author cannot archive publisher's version/PDF |
| Keywords: | NR2a, NR2b, NMDA receptors, gamma activation, schizophrenia |
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| Date Deposited: | 13 Oct 2015 13:15 |
| Last Modified: | 13 Oct 2015 13:15 |
| URI: | https://oak.novartis.com/id/eprint/4474 |