Le Grand, Darren, Gosling, Martin, Baettig, Urs, Bahra, Parmjit, Bala, Kamlesh, Brocklehurst, Cara, Budd, Emma, Butler, Rebecca, Cheung, Atwood, Collingwood, Stephen, Cox, Brian, Danahay, Henry, Edwards, Lee, Everatt, Brian, Glaenzel, Ulrike, Hall, Edward, Hatto, Julia, Howsham, Catherine, Hughes, Glyn, King, Anna, Koehler, Julia, Kulkarni, Swarupa, Lightfoot, Megan, Nicholls, Ian Michael, Page, Christopher, Pergl-Wilson, Giles, Robinson, Richard, Rowlands, David, Steward, Oliver, Taylor, Roger, Tranter, Pamela, Wagner, Beatrix, Williams, Gareth, Wright, Penny and Sandham, David (2021) Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease. Journal of Medicinal Chemistry, 64 (11). pp. 7241-7260. ISSN 0022-26231520-4804

Abstract

Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) ion channel are established as the primary causative factor in the devastating lung disease cystic fibrosis (CF). More recently, cigarette smoke exposure has been shown to be associated with dysfunctional airway epithelial ion transport, suggesting a role for CFTR in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). Here, the identification and characterization of a high throughput screening hit 6 as a potentiator of mutant human F508del and wild type CFTR channels is reported. The design, synthesis and biological evaluation of compounds 7 to 33 to establish structure activity relationships (SAR) of the scaffold are described, leading to the identification of clinical development compound icenticaftor (QBW251) 33, which has subsequently progressed to deliver two positive clinical proofs of concept in patients with CF and COPD and is now being further developed as a novel therapeutic approach for COPD patients.

Item Type:	Article
Keywords:	CFTR, COPD, Cystic Fibrosis
Date Deposited:	27 Jul 2021 00:45
Last Modified:	27 Jul 2021 00:45
URI:	https://oak.novartis.com/id/eprint/44259