Gallou, Fabrice (2021) Improved iGAL 2.0 Metric Empowers Pharmaceutical Scientists to Make Meaningful Contributions to U.N. Sustainable Development Goal 12. ACS Sustainable Chem. Eng.

Abstract

The large and steadily growing demand for medicines combined with their inherent resource-intense manufacturing necessitates their sustainable production. However, the absence of clearly defined standards impedes pharmaceutical companies from performing reliable Life Cycle Assessments of their medicines and assessing the true value of their sustainable development achievements. Guided by the unambivalent purpose of the UN Sustainable Development Goal 12, which aims at substantially reducing production waste by 2030, and driven by a vision to catalyze greener API manufacturing around the globe, we herein introduce iGAL 2.0 alongside the new Key Sustainability Indicators Convergence, including a new formula for Convergence and its potential utility in CASP algorithms. We demonstrate that iGAL 2.0 is based upon an improved statistical model that enables determination of meaningful API waste figures and early identification of potentially underperforming and environmentally more concerning processes, thereby delivering both environmental and economic value. We further illustrate how the metric is complemented by its scorecard companion to highlight the value-added of process scientists to their peers, managers and the general public with respect to API waste reduction. Taking everything into account, we believe that iGAL 2.0 can readily be adopted by pharmaceutical firms around the globe and thereby empower and inspires their scientists to make meaningful and significant contributions to UN SDG 12.

Item Type:	Article
Date Deposited:	07 Sep 2021 00:45
Last Modified:	07 Sep 2021 00:45
URI:	https://oak.novartis.com/id/eprint/44251