Parmentier, Michael, Gallou, Fabrice, Bordas, Vincent, Jakobi, Markus, Gosselin, Bryan, Palamini, Pierre and Wu, Bin-3 (2024) One-pot synthesis of substituted amides from nitriles under mild reaction conditions in aqueous surfactant TPGS-750-M. Catalysis today, 442. ISSN 09205861

Abstract

A copper-catalyzed amide bond synthesis is described under micellar aqueous reaction conditions with THF as
co-solvent. By using commercially available copper iodide catalyst, various amides were efficiently obtained
from a wide range of nitriles and aryl iodides. Aryls, heterocycles, and aliphatic amides were obtained in
moderate to excellent yields. Through optimization of the parameters, the process showed to be simple, scalable,
and sustainable. A Scale-up to 2 kg was performed of the hydration reaction supporting an API intermediate
synthesis.

Item Type:	Article
Keywords:	Nitrile hydration • copper-catalyzed amide coupling • Surfactant • Micelle • TPGS-750-M
Date Deposited:	18 Jul 2024 00:46
Last Modified:	18 Jul 2024 00:46
URI:	https://oak.novartis.com/id/eprint/43928