Wünsch, Isabell, Michel, Stephanie, Finke, Jan Henrik, John, Edgar, Juhnke, Michael and Kwade, Arno (2021) How can single particle compression and nanoindentation contribute to the understanding of pharmaceutical powder compression? European Journal of Pharmaceutics and Biopharmaceutics, 165 (n/a). pp. 203-218. ISSN 0939-6411

Abstract

The deformation behaviour of a powder is a crucial parameter in powder compaction and affects powder compressibility as well as compactibility. The classical approach for the characterization of the deformation behaviour is the performance of powder bulk compression experiments combined with the application of mathematical models, such as the model of Heckel, for the derivation of characteristic compression parameters. However, these models are typically empirical and the correlation of the derived parameters with the deformation behaviour is not fully physically proved. Single particle compression enables the in-depth investigation of the deformation behaviour of particulate materials. However, interpretation is usually limited to ideal shapes due to the easier accessibility of sizes for analysis based on geometric dimensions, such as the contact area between the compression tool and the particle.
In this study, single particle compression experiments were performed for the characterization of the deformation behaviour of common pharmaceutical excipients and active pharmaceutical ingredients with various, non-ideal particle morphologies and the findings are compared with the results from powder compression. It is found, that single particle compression is a useful tool for the qualitative characterization of the deformation behaviour and is useful for the improvement of the process understanding of powder compaction. However, the derivation of quantitative values and their transferability to powder compression is very limited.

Item Type:	Article
Date Deposited:	09 Jun 2021 00:45
Last Modified:	09 Jun 2021 00:45
URI:	https://oak.novartis.com/id/eprint/43463