Ramurthy, Savithri, Costales, Abran, Aikawa, Mina, Amiri, Payman, Jansen, Johanna, Lin, Song, Ma, Sylvia, Renhowe, Paul, Shafer, Cynthia, Subramanian, Sharadha, Sung, L and Verhagen, J (2011) Design and Synthesis of 5,6-fused Heterocyclic Amides as Raf Kinase Inhibitors. Bioorganic Medicinal Chemistry Letters, 21 (11). pp. 3286-3289. ISSN 0960-894X

Abstract

Two novel scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan-Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokinetic parameters.

Item Type:	Article
Related URLs:	Publisher http://www.ncbi.nlm.nih.gov/pubmed?term=...
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	Benzoxazoles, benzothiazoles, raf inhibitors
Related URLs:	Publisher http://www.ncbi.nlm.nih.gov/pubmed?term=...
Date Deposited:	13 Oct 2015 13:15
Last Modified:	13 Oct 2015 13:15
URI:	https://oak.novartis.com/id/eprint/4316