Bello, Claudia, Dal Bello, Giovanna, Grossi, Francesco, Patrone, Franco, Ballestrero, Alberto, Dupuis, Marc, Sordat, Bernard, Nencioni, Alessio, Zimmermann, Kaspar, Loretan, Jacqueline, Wartmann, Markus, Vogel, Pierre, Cea, Michele, Motta, Giulia, Moran, Eva, Aubry, Dominique, Nahimara, Aimable, Duchosal, Michel A., Fruscione, Floriana and Pronzato, Paolo (2011) Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols. BIOORGANIC & MEDICINAL CHEMISTRY, 19 (24). pp. 7720-7727. ISSN 0968-0896

Abstract

New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. (2R,3R,4S)-(Oleyloxymethyl)pyrroli¬dine-3,4-diol (13, IC50 ~2 uM) and its C18-analogues (IC50 < 10 uM) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC50 ~8 uM) growth of JURKAT cells.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed?term=...
Additional Information:	DOES NOT CONTAIN ANY NOVARTIS COMPOUNDS.
Keywords:	breast cancer iminoalditols Jurkat cells oleyl derivative
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed?term=...
Date Deposited:	13 Oct 2015 13:15
Last Modified:	13 Oct 2015 13:15
URI:	https://oak.novartis.com/id/eprint/4297