Wuensch, Isabell, Finke, Jan, John, Edgar, Juhnke, Michael and Kwade, Arno (2021) The influence of particle size on the application of compression and compaction models for tableting. International journal of pharmaceutics, 599 (n/a). 120424-n/a. ISSN 0378-5173

Abstract

The physical characteristics of raw materials determine powder compression and compaction performance as
relevant in pharmaceutical processes. For instance, the influence of initial particle size on powder compression
and the resulting strength of specimen are highly complex and are still not sufficiently understood. Existing
studies are often limited to materials with well-defined deformation behaviour, such as purely brittle or ductile.
However, the deformation behaviour of active pharmaceutical ingredients (APIs) is often more complex. In this
study, the influence of initial particle size on powder compressibility and compactibility is systematically
characterized by consideration of in-die compressibility, specific energies, quick elastic recovery, tablet porosity
and, tensile strength for the binder microcrystalline cellulose and three APIs. The decrease of particle size leads
to an increase of the resistance against compression by trend and probably to a different contribution of the
acting deformation mechanisms. The compactibility is increased with decreasing particle size because of the
increasing number of bonds in a cross-sectional area of the tablet, as found by the application of the model of
Rumpf. Furthermore, it is found that the model of Rumpf combined with the JKR model provides a meaningful
property function to estimate tablet tensile strength.

Item Type:	Article
Date Deposited:	24 Mar 2021 00:45
Last Modified:	24 Mar 2021 00:45
URI:	https://oak.novartis.com/id/eprint/42687