Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Tools
Tools
Erbel, Paulus, Schiering, Nikolaus, D'Arcy, Allan, Renatus, Martin, Kroemer, Markus, Lim, Siew Pheng, Yin, Zheng, Keller, Thomas, Vasudevan, Subhash and Hommel, Ulrich (2006) Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nature Structural & Molecular Biology, 13 (4). pp. 372-373. ISSN 1545-9993
Abstract
The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Related URLs: | |
| Date Deposited: | 14 Dec 2009 14:00 |
| Last Modified: | 31 Jan 2013 01:17 |
| URI: | https://oak.novartis.com/id/eprint/425 |