Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.
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Osborne, Colin, Leitner, Ingrid, Hofbauer, Bettina, Fielding, Ceri A, Favre, Bertrand and Ryder, Neil (2006) Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine. Antimicrobial Agents and Chemotherapy, 50 (6). pp. 2234-2236. ISSN 0066-4804
Official URL: http://aac.asm.org/cgi/content/full/50/6/2234?view...
Abstract
We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.
Item Type: | Article |
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Additional Information: | author can archive post-print (ie final draft post-refereeing); but on personal or university-hosted websites only |
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Date Deposited: | 14 Dec 2009 14:00 |
Last Modified: | 14 Dec 2009 14:00 |
URI: | https://oak.novartis.com/id/eprint/406 |