Zhang, Yun, Mainolfi, Nello, Patel, Sejal and Timothy, Jamison/F (2011) Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing. Journal of Organic Letters, 13 (2). pp. 280-283. ISSN 1523-7060

Abstract

A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.

Item Type:	Article
Related URLs:	http://pubs.acs.org/doi/abs/10.1021/ol10... http://www.ncbi.nlm.nih.gov/pubmed?term=...
Additional Information:	Archiving not formally supported
Keywords:	flow, Ullmann condensation, Sonogashira coupling, decarboxylation, copper tube reactor
Related URLs:	http://pubs.acs.org/doi/abs/10.1021/ol10... http://www.ncbi.nlm.nih.gov/pubmed?term=...
Date Deposited:	13 Oct 2015 13:15
Last Modified:	13 Oct 2015 13:15
URI:	https://oak.novartis.com/id/eprint/3948