The dark side of fluorine
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Pan, Yue (2019) The dark side of fluorine. ACS Medicinal Chemistry Letters. pp. 1016-1019. ISSN 19485875
Official URL: https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b...
Abstract
Despite the perceived stability of the C-F bond, chemical instability and drug-metabolizing enzymes can lead to its cleavage. The resulting release of fluoride and formation of certain metabolites may cause safety issues and warrant the medicinal chemists' attention.
Item Type: | Article |
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Keywords: | CYP TDI defluorination Fluorine reactive metabolite |
Date Deposited: | 27 Aug 2019 00:45 |
Last Modified: | 27 Aug 2019 00:45 |
URI: | https://oak.novartis.com/id/eprint/39439 |