Gallou, Fabrice (2019) Bridging the gap between transition metal and biocatalysis. Nature, 10. p. 2169.

Abstract

In our quest to attain synergistic processes involving chemo- and bio-catalysis, it has been discovered that aqueous solutions containing 2 wt % of the designer surfactant TPGS-750-M not only is compatible with enzymes, but also enhances their activity. Indeed, the lipophilic core of the micelles is suspected to act as a reservoir for substrates/products, avoiding noncompetitive inhibition of the enzyme. Numerous examples of cross-coupling reactions followed by asymmetric ketone reductions mediated by alcohol dehydrogenases (ADH) are reported, all run in 1-pot under mild conditions. Various transition metal catalysts based on Pd, Cu, Rh, and Au proved to be innocuous towards enzymatic activity, making this process suitable for a broad range of tandem organic transformations.

Item Type:	Article
Date Deposited:	16 Jul 2019 00:45
Last Modified:	16 Jul 2019 00:45
URI:	https://oak.novartis.com/id/eprint/38361