Yamaura, Takeshi, Kasaoka, Tatsuhiko, KANEKO, NAOKO, Kimura, Masaaki and Hatakeyama, Shinji (2019) Evaluation of therapeutic effects of FAK inhibition in murine models of atherosclerosis. BMC research notes, 12. p. 200. ISSN 1756-0500

Abstract

Objective: Therapeutic effects of focal adhesion kinase (FAK) inhibition using a small molecule inhibitor was evaluated in apolipoprotein E (apoE) knockout (KO) and low-density lipoprotein receptor (LDLr) KO mouse atherosclerosis models.
Results: The prevention trial consisted of 8-week concurrent treatment with a high fat (HF) / high cholesterol (HC) diet. The intervention trial consisted of 6- and 8-week treatment after 6- and 8-week pre-loading of a HF/HC diet in apoE KO and LDLr KO mice, respectively. The inhibitor was admixed with a HF/HC diet and mice were given free access to the admixture. The FAK inhibitor exhibited marked inhibition against the development of the atherosclerosis in both of prevention and intervention trials at a dose of 0.03% without showing any remarkable toxic properties in biochemical examinations. These results indicated that FAK inhibition might be a possible candidate for novel therapeutic targets against atherosclerosis.

Item Type:	Article
Date Deposited:	18 Apr 2019 00:45
Last Modified:	18 Apr 2019 00:45
URI:	https://oak.novartis.com/id/eprint/38234