The role of sphingosine and ceramide kinases in inflammatory responses.
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Baumruker, Thomas, Bornancin, Frederic and Billich, Andreas (2005) The role of sphingosine and ceramide kinases in inflammatory responses. Immunology Letters, 96 (2). pp. 175-185. ISSN 0165-2478
Abstract
The 1-phosphates of sphingosine and ceramide (S1P and C1P) have emerged as key representatives of a new group of lipid signalling molecules. S1P is known to act both as an extracellular mediator and as an intracellular 'second messenger,' while C1P currently is only known for its intracellular actions. Therefore, sphingosine and ceramide kinases, the enzymes involved in the generation of these lipid mediators, are now in the spotlight. This review summarizes current information on structure, localization, substrate specificity, activation, and binding partners of these kinases, and then focuses on discoveries in relation to immune cell regulation and inflammation, addressing in particular mast cell activation and degranulation, IL-12 signalling, prostaglandin biosynthesis, monocyte activation, and neutrophil priming.
| Item Type: | Article |
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| Additional Information: | can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Keywords: | Ceramide kinase; Immune cells; Signalling; Inflammation; Sphingosine kinase |
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| Date Deposited: | 14 Dec 2009 14:07 |
| Last Modified: | 31 Jan 2013 01:31 |
| URI: | https://oak.novartis.com/id/eprint/38 |