Quinazolinedione sulfonamides: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity
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Koller, Manuel, Lingenhoehl, Kurt, Schmutz, Markus, Vranesic, Ivan-Toma, Kallen, Joerg, Auberson, Yves, Carcache, David, Mattes, Henri, Ofner, Silvio, Orain, David and Urwyler, Stephan (2010) Quinazolinedione sulfonamides: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity. Bioorganic and medicinal chemistry letters, 21 (11). pp. 3358-3361. ISSN 0960-894X
Official URL: http://www.sciencedirect.com/science/article/pii/S...
Abstract
Quinazoline-2,4-diones with a sulfonamide group attached to the N(3) ring atom constitute a novel class of competitive AMPA receptor antagonists. One of the synthesized compounds, 28, shows nanomolar receptor affinity, whereas other examples of the series display oral anticonvulsant activity in animal models.
| Item Type: | Article |
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| Keywords: | AMPA receptor antagonist Glutamate receptor Anticonvulsive agents Quinazoline-2,4-dione sulfonamides |
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| Date Deposited: | 13 Oct 2015 13:15 |
| Last Modified: | 13 Oct 2015 13:15 |
| URI: | https://oak.novartis.com/id/eprint/3794 |