Iyer, Shwetha and Malyala, Padma (2019) Long-Acting Intraocular Delivery Strategies for Biological Therapy of Age-Related Macular Degeneration- A Review Article. Journal of controlled release.

Abstract

Age-related macular degeneration (AMD) is one of the leading causes of central vision loss in the elderly population. Treatment regimens for AMD, especially with biological agents, are complicated due to anatomical and physiological barriers, as well as administration of high doses and frequent regimens. Some clinical examples include monthly intravitreal administration of anti-VEGF antibody Lucentis® from Genentech and aflibercept (Eylea®) from Regeneron Pharmaceuticals. Long-acting sustained intraocular drug delivery provides promising solutions, such as Vitrasert® fromBausch & Lomb, an intravitreal implant made of a biodegradable polymer, poly (D,L-lactic co glycolic acid (PLGA), and can be used as a guiding reference to formulate sustained delivery systems. In this review, we discuss the anatomy and physiology of the eye, barriers to delivery, pathology of AMD, opportunities for biological therapeutics, and future prospects of intraocular delivery strategies that are in development for treatment of AMD.

Item Type:	Article
Date Deposited:	06 Feb 2019 00:45
Last Modified:	06 Feb 2019 00:45
URI:	https://oak.novartis.com/id/eprint/37924