Stoeckli, Markus, Staab, Dieter, Schweitzer, Alain, Gardiner, James and Seebach, Dieter (2007) Imaging of a beta-peptide distribution in whole-body mice sections by MALDI mass spectrometry. Journal of the American Society for Mass Spectrometry, 18 (11). pp. 1921-1924. ISSN 1044-0305

Abstract

Mass spectrometric imaging was applied to assess compound distributions on whole-body sections of mice after i.v. dosing of a beta-peptide and an alpha-peptide control. Animals were sacrificed at different time points (5 min, 1 h, 24 h) post-dose, providing simultaneous spatial as well as kinetic information. As a result of this study, no detection of the alpha-peptide control was observed at 1 h post-dose, while retention of the beta-peptide was observed for longer than 24 h post-dose.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.jasms.2007.08.005
Additional Information:	author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez... doi:10.1016/j.jasms.2007.08.005
Date Deposited:	14 Dec 2009 14:00
Last Modified:	31 Jan 2013 01:18
URI:	https://oak.novartis.com/id/eprint/377