Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response
Fendt, Markus, Buchi, Melanie, Buerki, Hugo, Imobersteg, Stefan, Ricoux, Berangere, Suply, Thomas and Sailer, Andreas (2010) Neuropeptide S receptor deficiency modulates spontaneous locomotor activity and the acoustic startle response. Behavioral Brain Research. ISSN 0166-4328
Abstract
The present study investigated the phenotype of heterozygous and homozygous neuropeptide S receptor (Npsr) deficient C57BL/6 mice in NPS- and cocaine induced hyperactivity, spontaneous and reactive locomotor activity, elevated plus maze, conditioned fear, and prepulse inhibition of the acoustic startle response. In Npsr-deficient mice, a strong reduction of spontaneous locomotor activity and of the startle magnitude was observed; heterozygous mice had an intermediate phenotype. In the other experiments, Npsr deficiency leads to no or only a very modest phenotype. These results support an important role of neuropeptide S in regulating locomotor activity.
Item Type: | Article |
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Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
Keywords: | Acoustic startle response; anxiety; circadian rhythm; freezing; prepulse inhibition |
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Date Deposited: | 13 Oct 2015 13:15 |
Last Modified: | 13 Oct 2015 13:15 |
URI: | https://oak.novartis.com/id/eprint/3749 |