Accelerating the discovery of new drug targets with chemical proteomics
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Cheung, Atwood and Jain, Rishi (2010) Accelerating the discovery of new drug targets with chemical proteomics. IDrugs, 13 (12). pp. 862-868. ISSN 1369-7056
Official URL: http://www.biomedcentral.com/idrugs/
Abstract
The application of chemical proteomics to new target discovery can lead to a rapid understanding of disease mechanism and new therapeutic methods. Successful application includes a thorough understanding of SAR and the validation of target relevance using multiple genetic and biochemical methods. This feature review highlights several successful applications of chemical proteomics and outlines the strategy and approaches that lead to the discovery of novel therapeutic targets.
| Item Type: | Article |
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| Keywords: | chemical proteomics, target identification, affinity chromatography, chemical genetics, signaling pathways, drug targets, cell-based assays |
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| Date Deposited: | 13 Oct 2015 13:15 |
| Last Modified: | 13 Oct 2015 13:15 |
| URI: | https://oak.novartis.com/id/eprint/3617 |