Treatment of Patients with Cardiovascular Disease with L-4F, an Apo-A1 mimetic, Did Not Improve Select Biomarkers of HDL Function
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Watson, Catherine, Weissbach, Nicole, Kjems, Lise, Ayalasomayajula, Surya, Zhang, Yiming, Chang, Ih, Navab, Mohamad, Hama, Susan, Hough, Greg, Reddy, Srinivasa, Soffer, Daniel, Rader, Daniel, Fogelman, Alan and Schecter, Alison (2010) Treatment of Patients with Cardiovascular Disease with L-4F, an Apo-A1 mimetic, Did Not Improve Select Biomarkers of HDL Function. Journal of Lipid Research, 52 (2). pp. 361-373. ISSN 0022-2275
Abstract
L-4F, an apolipoprotein A-I (apoA-I) mimetic peptide (also known as APL180), was administered daily by either intravenous (IV) infusion for 7 days or by subcutaneous (SC) injection for 28 days in patients with coronary heart disease in two distinct clinical studies. L-4F was well tolerated at all doses tested. Despite achieving plasma levels (mean maximal plasma concentration of 2,907 ng/ml and 395 ng/ml, following IV infusion and SC injection, respectively), that were effective in previously published animal models, treatment with L-4F, as assessed by biomarkers of HDL function such as HDL-inflammatory index (HII), and paraoxonase activity, did not improve. Paradoxically, there was a 49% increase in high-sensitivity C-reactive protein (hs-CRP) levels after seven IV infusions of 30 mg L-4F (P < 0.05; compared with placebo) and a trend for hs-CRP increase in subjects receiving 30 mg SC injection for 28 days. In a subsequent, ex vivo study, addition of L-4F at concentrations of 150, 375, or 1,000 ng/ml to plasma from subjects prior to L-4F treatment resulted in significant dose-dependent HII improvement. In conclusion, in vivo L-4F treatment, delivered by either SC injection or IV infusion, did not improve HDL functional biomarkers despite achieving plasma levels that improved identical biomarkers ex vivo and in animal models.
| Item Type: | Article |
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| Additional Information: | author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used |
| Keywords: | ApoA-I mimetic peptides; Atherosclerosis, HDL; C-reactive protein; Coronary Heart Disease; Diabetes; L-4F; Lipoproteins |
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| Date Deposited: | 13 Oct 2015 13:15 |
| Last Modified: | 13 Oct 2015 13:15 |
| URI: | https://oak.novartis.com/id/eprint/3615 |