Gallou, Fabrice and Lipshutz, Bruce (2018) B-Alkyl sp3-sp2 Suzuki-Miyaura Couplings Under Mild Aqueous Micellar Conditions. Organic letters, 20 (10). pp. 2902-2905. ISSN 1523-7052; 1523-7060

Abstract

Use of B-sp3-alkyl reagents for Suzuki-Miyaura couplings under aqueous micellar catalysis conditions is reported herein. Studies
as to substrate scope, use in a 4-step, 1-pot sequence, and reaction medium recycling exemplify the synthetic utility of this technology.
OBBD (B-alkyl-9-oxa-10-borabicyclo[3.3.2]decane) derivatives are easily made and utilized for couplings under mild conditions. Comparisons
were also made between OBBD and 9-BBN (B-alkyl-9-borabicyclo[3.3.1]nonane) derivatives as reaction partners.

Item Type:	Article
Date Deposited:	05 Jun 2018 00:45
Last Modified:	05 Jun 2018 00:45
URI:	https://oak.novartis.com/id/eprint/35946