Ruff, Yves and Berst, Frederic (2018) Efficient copper-catalyzed amination of DNA-conjugated aryl iodides under mild aqueous conditions. MedChemComm. ISSN 2040-2511; 2040-2503

Abstract

Herein, we describe the development of a copper-catalyzed N-arylation of DNA-conjugated aryl iodides with aliphatic amines. This protocol leverages a novel ligand, 2-((2,6-dimethoxyphenyl)amino)-2-oxoacetic acid, to effect the transformation in aqueous DMSO, under mild conditions, in air, making it an ideal candidate for the synthesis of DNA-encoded libraries.

Item Type:	Article
Date Deposited:	31 Jul 2018 00:45
Last Modified:	31 Jul 2018 00:45
URI:	https://oak.novartis.com/id/eprint/35390