Gallou, Fabrice (2018) Inspiring process innovation via a breakthrough green manufacturing metric: iGAL. Green chemistry, 20. pp. 2206-2211.

Abstract

Following our goal to devise a unified green chemistry metric that inspires innovation in sustainable drug manufacturing across the pharmaceutical industry, we herein disclose our efforts leading to the breakthrough ‘innovation Green Aspiration Level’ (iGAL) methodology. Backed by the statistical analysis of 64 drug manufacturing processes across 12 companies, we find that iGAL affords a suitable proxy for molecular complexity and presents a valuable molecular weight-based ‘fixed’ goal. iGAL thereby accurately captures the impact of green process inventiveness and improvements, rendering it an outstanding innovation-driven green metric. We conclude by introducing the comprehensive, yet easy-to-use and readily adaptable Green Chemistry Innovation Scorecard web calculator, whose graphical output clearly and effectively illustrates the impact of innovation on waste reduction during drug manufacture.

Item Type:	Article
Date Deposited:	12 Jun 2018 00:45
Last Modified:	12 Jun 2018 00:45
URI:	https://oak.novartis.com/id/eprint/35106