Moggs, Jonathan and Terranova, Remi (2018) Chromatin dynamics underlying latent responses to xenobiotics. Toxicology research, 7. pp. 606-617.

Abstract

Pleiotropic xenobiotics can trigger dynamic alterations in mammalian chromatin structure and function but many of these are likely non-adverse and simply reflect short-term changes in DNA transactions underlying normal homeostatic, adaptive and protective cellular responses. However, it is plausible that a subset of xenobiotic-induced perturbations of somatic tissue or germline epigenomes result in delayed-onset and long-lasting adverse effects, in particular if they occur during critical stages of growth and development. These could include reprogramming, dedifferentiation, uncontrolled growth, and cumulative toxicity effects through molecular memory of prior xenobiotic exposures or altered susceptibility to subsequent xenobiotic exposures. Here we discuss the current evidence for epigenetic mechanisms underlying latent responses to xenobiotics, including cases where molecular epigenetic changes are prodromal to overt morphologic or functional toxicity phenotypes.

Item Type:	Article
Keywords:	epigenetics toxicology safety assessment xenobiotics
Date Deposited:	17 Jul 2018 00:45
Last Modified:	17 Jul 2018 00:45
URI:	https://oak.novartis.com/id/eprint/34895