Galyan, Keith and Reilly, John (2018) Green Chemistry Approaches for the Purification of Pharmaceuticals. Current Opinion in Green and Sustainable Chemistry.

Abstract

To enable R&D of new drug products with a more green process emphasis, a full understanding of the impact of chromatography in the discovery phase of drug development is crucial. With large quantities of small scale (<1000mg) separations typically evaluated and purified, a chromatographic technique needs to be easily integrated into workflows and readily robust. At Novartis, integration of supercritical fluid chromatography (SFC) has allowed for increases in productivity, decreases in toxic/hazardous solvent consumption and a more green approach to chromatography. The purpose of this review is to introduce the reader to new techniques available to organizations for the analysis and purification of mg-kg scale purifications that are routinely handled within discovery. Evaluation of a variety of techniques available to the industry has led to the implementation of SFC, with some of the pros of each technique noted below: An overview of enantiomeric purification methodologies is highlighted below in Table 1.

Item Type:	Article
Keywords:	SFC, Chromatography, purification, green
Date Deposited:	06 Jun 2018 00:45
Last Modified:	06 Jun 2018 00:45
URI:	https://oak.novartis.com/id/eprint/34812