Ji, Yan, Jin , Jin Y., Hyman, David, Kim, Geoffrey and Suri, Ajit (2018) Challenges and Opportunities in Dose Finding in Oncology and Immuno-oncology. Clinical and Translational Science, 00. pp. 1-7.

Abstract

Today’s cancer therapy has made substantial progresses. Recent success in immuno-oncology (IO) has generated enormous excitement and expectation. With the existing and novel therapies, combination therapies provide opportunities to coordinate actions on multiple targets, and could enhance activity in broader population with less drug resistance. However, these advances also raised tremendous challenges to balance efficacy and safety in oncology drug development. Hence, dose finding has become more urgent than ever in cancer therapy. This review summarizes the challenges and opportunities in dose selection in oncology and IO. The opportunities of utilizing modeling and simulation (M&S) during both early and late phase oncology drug development were highlighted. The need of multi-disciplinary collaboration across functions and affiliations was emphasized.

Item Type:	Article
Date Deposited:	17 Feb 2018 00:45
Last Modified:	17 Feb 2018 00:45
URI:	https://oak.novartis.com/id/eprint/34439