Lopez, John (2018) N-Butylpyrrolidone as a green solvent for Solid Phase Peptide Synthesis. Organic process research & development, 22. pp. 494-503. ISSN 1520-586X; 1083-6160

Abstract

By means of a systematic approach, several candidate solvents were tested for their feasibility of replacing the reprotoxic DMF as solvent used in large scale manufacture of peptide by the Solid Phase Peptide Synthesis (SPPS) methodology. N-Butylpyrrolidone (NBP) was found to be a viable green alternative solvent to replace DMF, appropriate to all stages of the SPPS.

Item Type:	Article
Date Deposited:	08 May 2018 00:45
Last Modified:	08 May 2018 00:45
URI:	https://oak.novartis.com/id/eprint/33958