Smith, Aaron, Ni, ZJ, Poon, Daniel, Huang, Zilin, Chen, Zheng, Zhang, Qiong, Tandeske, Laura, Merritt, Hanne, Shoemaker, Kevin, Chang, John, Kaufman, Sue, Huh, Kay, Murray, Jeremy, Appleton, Brent A., Jacob, Sandra, Scheufler, Clemens, Kanazawa, Takanori, Jansen, Hanneke, Stuart, Darrin and Shafer, Cynthia (2017) Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors. Bioorganic and Medicinal Chemistry Letters. ISSN 14643405

Abstract

A series of imidazo[1,2-a]pyridin-6-yl-benzamide analogs was designed as inhibitors of B-RAFV600E. Medicinal chemistry techniques were employed to explore the SAR for this series and improve selectivity versus P38 and VEGFR2.

Item Type:	Article
Keywords:	Kinase MAPK RAF
Date Deposited:	29 Nov 2017 00:45
Last Modified:	25 Jan 2019 00:45
URI:	https://oak.novartis.com/id/eprint/33114