Hu, Tiancen, Sprague, Elizabeth, Fodor, Michelle, Stams, Travis, Clark, Kirk and Jacob, Sandra (2017) The impact of structural biology in medicine illustrated with four case studies. Journal of Molecular Medicine. pp. 1-11. ISSN 14321440

Abstract

The contributions of structural biology to drug discovery have expanded over the last 20 years from structure-based ligand optimization to a broad range of clinically relevant topics including the understanding of disease, target discovery, screening for new types of ligands, discovery of new modes of action, addressing clinical challenges such as side effects or resistance, and providing data to support drug registration. This expansion of scope is due to breakthroughs in the technology, which allow structural information to be obtained rapidly and for more complex molecular systems, but also due to the combination of different technologies such as X-ray, NMR, and other biophysical methods, which allows one to get a more complete molecular understanding of disease and ways to treat it. In this review, we provide examples of the types of impact molecular structure information can have in the clinic for both low molecular weight and biologic drug discovery and describe several case studies from our own work to illustrate some of these contributions.

Item Type:	Article
Keywords:	Allosteric Conformation Drug discovery Inhibitors Structural biology
Date Deposited:	30 Sep 2017 00:45
Last Modified:	25 Jan 2019 00:45
URI:	https://oak.novartis.com/id/eprint/32146