Mandrelli, Francesca, Buco, Alessia, Piccioni , Lorenzo, Renner, Florian, Guelat, Bertrand, Martin, Benjamin, Schenkel, Berthold and Venturoni, Francesco (2016) Scale-up of continuous biphasic liquid/liquid reactions under super-heating conditions: methodology and reactor design. Green Chem.. ISSN 1463-92621463-9270

Abstract

Biphasic liquid/liquid reactions are commonplace, however their scale-up under super-heating conditions are not. An even more challenging effort has to be expected in case of a large scale continuous production process, which also includes the development in lab scale, the selection and design of the continuous reaction equipment. However, by running chemistry above the boiling point of the solvent, the solvent selection can be widened to include green solvents and continuous processing guarantee a limited and safe footprint. Herein is reported a systematic methodology for the development and scale-up of a biphasic reaction under super-heating conditions, as well as the design of a continuous reactor column suitable for handling such conditions. Taking the alkylation of benzylamine with 1,5-dibromopentane as model reaction, kinetic determination and fluid dynamic characterization of the biphasic media have been instrumental for a successful scale-up concept which was proven in a custom-made hastelloy reactor column.

Item Type:	Article
Date Deposited:	06 Jan 2017 00:45
Last Modified:	06 Jan 2017 00:45
URI:	https://oak.novartis.com/id/eprint/31160