Linton, Steven D, Karanewsky, Donald S, Ternansky, Robert J, Chen, Ning, Guo, Xian, Jahangiri, Kathy G, Kalish, Vincent J, Meduna, Steven P, Robinson, Edward D, Ullman, Brett R, Wu, Joe C, Pham, Brian, Kodandapani, Lalitha, Smidt, Robert, Diaz, Jose-Luis, Fritz, Lawrence C, von Krosigk, U, Roggo, Silvio, Schmitz, Albert and Tomaselli, Kevin J (2002) Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization. Bioorganic & Medicinal Chemistry Letters, 12 (20). pp. 2973-2975. ISSN 0960-894X

Abstract

A new structural class of broad spectrum caspase inhibitors was optimized for its activity against caspases 1, 3, 6, 7, and 8. The most potent compound had low nanomolar broad spectrum activity, in particular, single digit nanomolar inhibitory activity against caspase 8.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
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Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	29 Apr 2010 23:45
Last Modified:	01 Feb 2013 00:49
URI:	https://oak.novartis.com/id/eprint/2862