Han, Wooseok, Ding , Yu, Xu, Yongjin, Pfister, Keith, Zhu, Shejin, Warne, Robert, Doyle, Mike, Aikawa, Mina, Amiri, Payman, Appleton, Brent, Stuart, Darrin, Fanidi, Abdallah and Shafer, Cynthia (2016) Discovery of A Selective and Potent Inhibitor of MNK Kinase 1/2 Utilizing Structure-Based Drug Design. Journal of Medicinal Chemistry, 59 (7). pp. 3034-3045. ISSN 0022-26231520-4804

Abstract

The discovery of a highly potent and selective small molecule inhibitor 8 for in vitro target validation of MNK1/2 kinases is described. The aminopyrazine benzimidazole series was derived from an HTS hit and optimized by utilization of a docking model, conformation analysis, and binding pocket comparison against anti-targets.

Item Type:	Article
Date Deposited:	27 Apr 2016 23:45
Last Modified:	27 Apr 2016 23:45
URI:	https://oak.novartis.com/id/eprint/28344