Busche, Marc Aurel, Grienberger, Christine, Keskin, Aylin Derya, Song, Beomjong, Neumann, Ulf, Staufenbiel, Matthias, Förstl, Hans and Konnerth, Arthur (2015) Decreased amyloid-β but increased neuronal hyperactivity by immunotherapy in Alzheimer´s models. Nature Neuroscience.

Abstract

Among the most promising approaches to treat Alzheimer´s disease (AD) is
immunotherapy with amyloid-β (Aβ)-targeting antibodies. Here, by using in vivo twophoton
imaging in mouse models, we demonstrate that two different anti-Aβ antibodies
used for treatment are ineffective in repairing neuronal dysfunction and can cause an
increase in cortical hyperactivity. This unexpected finding provides a possible cellular
explanation for the lack of cognitive improvement by immunotherapy in human studies.

Item Type:	Article
Keywords:	Alzheimer's disease, immunotherapy, antibody, neuronal activity
Date Deposited:	06 Jan 2016 00:45
Last Modified:	06 Jan 2016 00:45
URI:	https://oak.novartis.com/id/eprint/27477