Rusch, Marion, Ngo, Guillaume, Osmont, Elodie, Wallace, Owen, Bouwmeester, Antonius, Press, Neil and Bouchez, Laure (2015) Novel chitosan-modified surfaces to study stem cell receptors and signaling. biomaterial science (RSC).

Abstract

Stem cells have great potential for understanding early development, treating human diseases, tissue trauma and early phase drug discovery. The factors that control the regulation of stem cell survival, proliferation, migration and differentiation are still emerging. Some evidences now exist demonstrating the potent effects of various receptors and G-protein coupled receptor (GPCR)-ligands on the biology of stem cells. In this context, we developed novel synthetic surfaces to study stem cell receptors and their signaling, with a particular interest in the biocompatible material chitosan. These synthetic surfaces will present a series of small molecules that are anticipated to act both as agonists/ or antagonists and targeting agents of protein receptors and/or growth factor receptors located at the surface of our stem cells of choice. A special interest was given to extracellular receptor-ligand interactions and how they enhance and/ or inhibit their cellular responses, as well as how they activate/silence their connected pathway(s).

Item Type:	Article
Date Deposited:	17 May 2016 23:45
Last Modified:	17 May 2016 23:45
URI:	https://oak.novartis.com/id/eprint/26816