Walker, Dana and Ramiah, Shashi (2016) Veterinary Pathologists in Translational Pharmacology and Biomarker Integration in Drug Discovery and Development. Toxicologic Pathology.

Abstract

This manuscript highlights emerging roles for veterinary pathologists outside of traditional functions and in line with the translational research approach. Veterinary pathologists offer unique and valuable expertise towards addressing particular translational research and associated translational pharmacology questions, identifying gaps and risks in biomarker and pathology strategies and advancing translational research team decision-making. Veterinary pathologists’ attributes that are integral to the translational research approach include (i) well-developed understanding of comparative physiology, pathology and disease: (ii) extensive experience in interpretation and integration of complex data sets on whole body responses and utilizing this for deciphering pathogenesis and translating events between laboratory species and man; (iii) proficiency in recognizing differences in disease endpoints among individuals, animal species and strains and assessing correlations between these differences and other investigative (including biomarker) findings, and (v) strong background in a wide spectrum of research technologies that can address pathomechanistic questions and biomarker needs. Some of the more evident roles in which veterinary pathologists can offer their greatest contributions to address questions and strategies of translational research and biomarker integration will be emphasized.

Item Type:	Article
Date Deposited:	26 Apr 2016 23:45
Last Modified:	26 Apr 2016 23:45
URI:	https://oak.novartis.com/id/eprint/26528