Zou, Bin, Seh Yong, Leong, Ding, Mei and Smith, Paul William (2015) A mild and efficient synthesis of spiroquinolinones via an unexpected rearrangement. Tetrahedron Letters, 56 (44). pp. 6016-6018. ISSN 1873-3581

Abstract

A mild and efficient synthesis of spiroquinolinones 6 via condensation of chlorooxoindolines 5 and benzene-1,2-diamines 3 is reported. Instead of expected spirooxindole product 4′, spiroquinolinones 6 were isolated in up to 95% yield. A plausible mechanism involving an interesting ring rearrangement to form spiroquinolinones is proposed.

Item Type:	Article
Keywords:	Chlorooxoindolines Condensation reaction Diamines Mechanism Spiroquinolinones
Date Deposited:	25 Oct 2017 00:45
Last Modified:	25 Jan 2019 00:45
URI:	https://oak.novartis.com/id/eprint/26434