Busby, Scott (2015) MALDI High-Throughput Screening beyond 100,000 Samples per Day in Drug Discovery. Bruker Poster Note PN-05.

Abstract

Label-free methods based on mass spectrometry are rapidly expanding into HTS development. These MS-based methods include multiplexed LC-MS and SPE-MS techniques and have typical cycle times of between 6 and 30 seconds per sample. Using MALDI-TOF in HTS assays provides significant benefits over multiplexed LC-MS and SPE-MS techniques by dramatically increasing sample analysis speed. MALDI-TOF approaches can also significantly reduce costs and the amount of solvent/ chemical waste. This work focuses on the improvement of MALDI-TOF automation parameters to further increase sample analysis speed in HTS assays to more than 100,000 samples per day.

Item Type:	Article
Date Deposited:	31 May 2016 23:45
Last Modified:	06 Jul 2016 23:45
URI:	https://oak.novartis.com/id/eprint/26415