Rutkowska, Aleksandra, Dev, Kumlesh and Sailer, Andreas (2016) The Role of the Oxysterol/EBI2 Pathway in the Immune and Central Nervous Systems. Current drug targets, 17 (16). pp. 1851-1860. ISSN 1873-5592

Abstract

Oxysterols are pleiotropic messengers interacting with multiple receptor systems. One of the cognate receptors for oxysterols is EBI2, a G protein-coupled receptor highly expressed in the cells of the immune system. Here we discuss the receptor's role in the adapted immunity and inflammation as well as the receptor's expression and function in the CNS with the focus on astrocytes. We also discuss expression and signalling of oxysterol-producing enzymes such as CH25H and CYP7B1 in the CNS and the immune system. These steps will help to elucidate a possible role for this pathway in the physiology of the central and peripheral nervous system and its possible link to human disease.

Item Type:	Article
Keywords:	Adaptive Immunity Animals Astrocytes Central Nervous System Cytochrome P450 Family 7 Humans Immune System Inflammation Neurodegenerative Diseases Oxysterols Receptors, G-Protein-Coupled Signal Transduction Steroid Hydroxylases
Date Deposited:	12 Jul 2022 00:45
Last Modified:	12 Jul 2022 00:45
URI:	https://oak.novartis.com/id/eprint/25434