Generation of a monoclonal antibody agonist to toll-like receptor 4.
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Cohen, Steven, Gaskins, Chris and Nasoff, Marc (2005) Generation of a monoclonal antibody agonist to toll-like receptor 4. Hybridoma, 24 (1). pp. 27-35. ISSN 1554-0014
Abstract
Toll-Like Receptor 4 (TLR4) has recently been identified as the lipopolysaccharide (LPS) receptor. Upon stimulation of TLR4 with LPS, a Th1 type cytokine response is observed. This immune modulation is thought to have a potential benefit in anti-tumor therapy. We have generated a TLR4 antibody agonist (5D24.D4) that mimics the action of the natural ligand. 5D24.D4 and LPS stimulation of TLR4 leads to a similar response, including IL-8 secretion, activation of NF-kB-mediated transcription, and the induced expression of an overlapping set of target genes. 5D24.D4 may be beneficial as an adjuvant anti-tumor therapy.
| Item Type: | Article |
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| Additional Information: | archiving not formally supported by this publisher |
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| Date Deposited: | 14 Dec 2009 14:02 |
| Last Modified: | 31 Jan 2013 01:22 |
| URI: | https://oak.novartis.com/id/eprint/254 |