Gerspacher, Marc, Fairhurst, Robin, Mah, Robert, Roehn-Carnemolla, Esther, Furet, Pascal, Fritsch, Christine and Guthy, Daniel Alexander (2015) Discovery of a Novel Tricyclic 4H-Thiazolo[5',4':4,5]pyrano[2,3-c]pyridine-2-amino Scaffold and its Application in a PI3K Inhibitor with High PI3K Isoform Selectivity and Potent Cellular Activity. Bioorg. Med. Chem. Letters, 25 (17). pp. 3582-3584. ISSN 0960-894X

Abstract

A novel, previously undescribed 4H-thiazolo[5',4':4,5]pyrano[2,3-c]pyridine tricyclic scaffold has been discovered. The application of this novel chemotype leading to a potent and selective prototype PI3K inhibitor is described.

Item Type:	Article
Keywords:	Oncology, Phosphatidylinositol-3-kinase (PI3K), selective PI3K Inhibitor, 4H-Thiazolo[5',4':4,5]pyrano[2,3-c]pyridine-2-amino derivative
Date Deposited:	12 Oct 2016 00:45
Last Modified:	12 Oct 2016 00:45
URI:	https://oak.novartis.com/id/eprint/25268