Fouche, Marianne, Roth, Hans-Joerg, Masse, Florence, Furrer, David, Garcia Martin, Aimar and Ertl, Peter (2015) Hydroxymethyl salicylaldehyde-promoted ligation: a new functionalization for chemoselective ligations. Angewandte Chemie, Int. Ed., 17 (20). pp. 4936-4939. ISSN 1523-70601523-7052

Abstract

A new amide-forming ligation exhibiting an unprecedented selectivity for glycine is described herein. The distinguishing feature of this ligation is it's reliance on an ortho-hydroxymethyl salicylaldehyde ester at the C-terminus which allows, via an N,O-acetal intermediate, the formation of a native peptide bond.

Item Type:	Article
Date Deposited:	26 Apr 2016 23:45
Last Modified:	26 Apr 2016 23:45
URI:	https://oak.novartis.com/id/eprint/24857