Sommer, Ulrike, Morales, Johanna, Groenewegen, Andrea, Mueller, Annemarie, Naab, Julia, Woerly, Gaetane, Kamphausen, Esther, Marsot, Helene, Bennet, Patrick, Kakkanaiah, Vellalore and Vitaliti Garami, Alessandra (2015) Implementation of highly sophisticated flow cytometry assays in multi- center clinical studies: considerations and guidance. Bionalysis, Vol. 7 (No. 10). pp. 1299-1311. ISSN DOI 10.4155/bio.15.61

Abstract

the item has no formal formal abstract
as summary of the items the table of contents is given here:
Table of contents
1 Introduction:
1.1 Technical overview and applications of flow cytometry
1.2 Use of flow cytometry for biomarker analysis in human clinical studies
2 Development and Validation of flow cytometry assays for clinical use
2.1 Summary of key challenges
2.2 Considerations for the Validation of PhosFlow assays used for PK/PD assessment
3 Whole blood flow cytometry assays in multi-center clinical studies:
Immunophenotyping versus PhosFlow
3.1 On-site processing of whole blood samples
3.2 Stabilization of samples: stabilizing tubes or freezing of whole blood samples
3.3 Clinical study implementation
4 Summary and Future Perspectives:

Item Type:	Article
Keywords:	Flow cytometry, biomarkers, validation, clinical trial
Date Deposited:	12 Oct 2016 00:45
Last Modified:	12 Oct 2016 00:45
URI:	https://oak.novartis.com/id/eprint/24612