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Protein production and crystallization at the joint center for structural genomics.

Lesley, Scott and Wilson, Ian (2005) Protein production and crystallization at the joint center for structural genomics. Journal of Structural and Functional Genomics, 6 (2-3). pp. 71-79. ISSN 1345-711X

Abstract

By definition, structural genomics centers must be able to address a large number of diverse protein targets. The methods developed should permit parallel and cost-effective processing while allowing for the diverse nature of proteins. Our approach to this problem is a multi-tiered effort where targets are characterized and categorized by behavior and processed in parallel by appropriate methods. The Joint Center for Structural Genomics (JCSG) has applied this tactic to create a fully integrated and scaleable structure determination pipeline. Highlights of the development of the current pipeline for protein production and crystallization are presented here.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: high throughput; automated protein production; robotic crystallization; salvage pathways; protein characterization
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Date Deposited: 14 Dec 2009 14:02
Last Modified: 31 Jan 2013 01:23
URI: https://oak.novartis.com/id/eprint/240

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