Schweighauser, Manuel, Bacioglu, Mehtap, Fritschi, Sarah, Shimshek, Derya, Kahle, Philipp, Eisele, Yvonne and Jucker, Mathias (2014) Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts. Acta Neuropathologica.

Abstract

In summary, the present results indicate that a-synuclein seeds in brain tissue resist formaldehyde fixation as previously reported for Aβ. It is likely, albeit to be proven, that this is also true for aggregated tau other self-propagating pathogenic protein aggregates. These findings can now be exploited to further establish the relationship between the molecular architecture of a-synuclein lesions and individual pathogenesis and thereby exploit archived formalin-fixed brain material.

Item Type:	Article
Date Deposited:	13 Oct 2015 13:12
Last Modified:	13 Oct 2015 13:12
URI:	https://oak.novartis.com/id/eprint/23773