Hoegenauer, Klemens, Hinterding, Klaus and Nussbaumer, Peter (2010) S1P receptor mediated activity of FTY720 phosphate mimics. Bioorganic & Medicinal Chemistry Letters, 20 (5). pp. 1485-1487. ISSN 0960-894X

Abstract

Various carboxylic acids, phosphonic acids, sulfonic acids, tetrazoles as well as sulfonylhydantoins were prepared as phosphate mimics of the chiral aminophosphate 1-P to act as agonists on the S1P1 receptor. It was found that amino phosphonates and amino carboxylates are potent S1P1 binders. Beta-amino acid 11 could be shown to reversibly reduce blood lymphocyte counts in rats after p.o. administration.

Item Type:	Article
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Additional Information:	Author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords:	FTY720; S1P receptor agonist; Phosphate mimic
Related URLs:	http://www.ncbi.nlm.nih.gov/sites/entrez...
Date Deposited:	13 Oct 2015 13:16
Last Modified:	13 Oct 2015 13:16
URI:	https://oak.novartis.com/id/eprint/2369