Bouslimani, Amina , Porto, Carla , Rath, Christopher, Wang, Mingxun , Yurong , Guo , Gonzalez, Antonio , Berg-Lyon, Donna , Ackermann, Gail , Christensen , Gitte Julie Moeller , Teruaki , Nakatsuji , Zhang , Lingjuan , Borkowski , Andrew , Meehan , Michael , Dorrestein , Kathleen , Gallo , Richard , Bandeira, Nuno , Knight , Rob , Alexandrov , Theodore and Dorrestein , Pieter (2015) 3D molecular cartography of the human skin surface. PNAS.

Abstract

The human skin is an organ with a surface area of 1.5–2 m2 that
provides our interface with the environment. The molecular composition
of this organ is derived from host cells, microbiota, and
external molecules. The chemical makeup of the skin surface is
largely undefined. Here we advance the technologies needed to
explore the topographical distribution of skin molecules, using
3D mapping of mass spectrometry data and microbial 16S rRNA
amplicon sequences. Our 3D maps reveal that the molecular composition
of skin has diverse distributions and that the composition
is defined not only by skin cells and microbes but also by our daily
routines, including the application of hygiene products. The technological
development of these maps lays a foundation for studying
the spatial relationships of human skin with hygiene, the
microbiota, and environment, with potential for developing predictive
models of skin phenotypes tailored to individual health.

Item Type:	Article
Date Deposited:	13 Oct 2015 13:12
Last Modified:	13 Oct 2015 13:12
URI:	https://oak.novartis.com/id/eprint/22831